What Happens To Our Body When We Age?

We all know what aging looks like, but how does it actually happen?

9 Hallmarks of Aging

The hallmarks of aging — Image credits: NCBI

Genomic instability

Telomere attrition

  • First of all, our stem cells (cells that don’t have a specialized function) produce an enzyme called telomerase that rebuilds the pieces of telomeres lost in the cell division process. Specialized cells are not able to produce this useful enzyme themselves but we could activate them through telomerase therapy. A company working on this is Telocyte: using telomerase, they are rebuilding the telomeres of brain cells that became dysfunctional because of Alzheimer’s.
  • Secondly, cancer cells can rebuild their telomeres indefinitely. We don’t know exactly how they do it but, if we could understand the mechanism, we may be able to replicate it for our own cells.
Telomeres protect the integrity of our genetic information — Image credits: Metabolic Medicine

Epigenetic alterations

Our cells all have the same DNA but specific cells have specific active and inactive sections of this same DNA

Loss of proteostasis

  • Slow down the accumulation of damaged proteins.
  • Counteract their negative effects.
  • Destroy or remove these proteins.

Deregulated nutrient sensing

Mitochondrial dysfunction

Mitochondrial structure — Image credits: National Human Resource Genome Institute

Cellular senescence

Stem cell exhaustion

Altered intercellular communication

In our body, we have about 30,000,000,000,000 cells — Image credits: Healthline

Conclusion

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Tomorrow Biostasis GmbH

Tomorrow Biostasis GmbH

We are a Berlin based longevity company committed to advancing Biostasis technology and promoting it in a simple and transparent way. www.tomorrowbiostasis.com